The US Supreme Court has declined to hear Johnson & Johnson’s appeal over a pay-out to women who alleged that its talcum powder contained asbestos and caused them to develop ovarian cancer.
The healthcare giant must pay $2.1bn (£1.5bn) in damages to the women.
The top US court did not comment on its decision, but has left in place a 2018 verdict that favoured them.
Johnson & Johnson (J&J) said decades of independent research show the product is safe.
The company asked the court to review the penalty it had been given after it was upheld in Missouri in 2020.